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副研究员

焦晓臻

职 称:副研究员

所属科室:合成药物化学研究室

导师类别:硕士生导师

联系方式:010-63165241

所属重点实验室:

个人简介

1. 工作经历
2011.10—至今 太阳集团1088vip 副研究员
2004.10-2011.9 太阳集团1088vip 助理研究员
1997.9-2004.9 太阳集团1088vip 研究实习员
2. 教育背景
2013.9-2016.7 北京协和医学院 药物化学 博士
2000.9-2003.7 中国协和医科大学 药物化学 硕士
1993.9-1997.7 北京医科大学 药物化学 学士
3. 科研情况
作为主要完成人,参加了两个创新药物即具有抗肾衰的新药硝克柳胺(临床II期)及抗帕金森氏症的新药芬乐胺(已完成I期临床研究,正进入II临床)的研发工作。作为课题负责人主持了国家自然基金的青年基金及中央级公益性科研院所基本科研业务费等课题。并先后参加了国家自然基金、973项目、克林顿基金、十一五大平台、十二五侯选药,医科院创新工程,十三五大平台等科研项目。

研究方向

1.药物分子设计与合成
2.活性天然产物的全合成及结构修饰
3.创新药物的研发

发表论文

近期以第一作者或通讯联系人在Org. Lett., Bio.Chem., J Org. Chem., Org. & Bio. Chem., Bio. & Med. Chem. Lett., Tetrahedron等杂志发表SCI论文14篇,申请专利5项,授权专利6项。
发表论文:
1. Total Synthesis of the Proposed Structure of Characellide B, Yong Wang†, Zhenwei Wang†, Zhe Wang†, Xiaoyu Liu, Yingjun Jiang, Xiaozhen Jiao* and Ping Xie*, Org. Lett., 2021, 23, 3680-3684. (IF=6.091 )
2. (+)-Isocryptotanshinone derivatives and its simplified analogs as STAT3 signaling pathway inhibitors, Xiang Shi# , Ting ting Du #, Zhihui Zhang #, Xiaoyu Liu, Ying Yang , Nina Xue , Xiaozhen Jiao* , Xiaoguang Chen * , Ping Xie *, Bioorganic Chemistry , 127 (2022) ,106015. (IF=5.307)
3. Total Synthesis of (-)-Levesquamide, Yingjun Jiang, Xiaoyu Liu, Wenxuan Li, Xiaozhen Jiao*, Ping Xie*, J Org. Chem., 2023, 88, 3981-3986. (IF=4.198 )
4. Convenient synthesis of perhydrobenz[e]indene triketone, a key intermediate for the total synthesis of stelletins, Yang Cao, Xiaoyu Liu, Zhe Wang, Yuan Wang, Xiaozhen Jiao * and Ping Xie*, Org. & Bio. Chem., 2023, 21, 3850-3857. (IF=3.876)
5. Total synthesis of (±) commiphoranes C–D and their epimers,Xiaoyu Liu#, Haidong Deng#, Yingjun Jiang, Yang Cao, Zhe Wang, Xiaozhen Jiao * and Ping Xie, Org. & Bio. Chem., 2022, 20(10): 2102-2108.(IF=3.876)
6. Total Synthesis of Bysspectin A, Feilong Yang, Xiaoyu Liu, Xiang Shi, Yong Wang, Guoru Hu, Sheng Lin, Xiaozhen Jiao* and Ping Xie*, Tetrahedron, 2019, 75, 3101-3107.(IF=2.33 )
7. Asymmetric total synthesis of (t)-isocryptotanshinone and formal synthesis of (-)-cryptotansh- inone, Xiang Shi, Xiaoyu Liu, Feilong Yang, YongWang, ZhenweiWang, Xiaozhen Jiao*, Ping Xie*, Tetrahedron, 2019, 75, 3962-3967. (IF=2.33 )
8. Design, Synthesis and Biological Evaluation of Substituted (+)-SG-1 Derivatives as Novel anti-HIV Agents. Xiaoyu Liu,Panpan Chen, Xiaoyu Li, Mingyu Ba, Xiaozhen Jiao*, Ying Guo*, Ping Xie Bio. & Med. Chem. Lett., 2018, 28(10): 1699-1703 (IF=2.442)
9. Enantioselective Total Synthesis of Colomitides and their Absolute Configuration Determina- tion and Structural Revision. Hongguang Yang, Xiaoyu Liu, Xiaoyu Li, Xiang Shi, Feilong Yang, Xiaozhen Jiao*, Ping Xie*. Org. & Bio. Chem., 2017, 15, 3728- 3735. (IF=3.423 )
10. Discovery of novel N-substituted-prolinamido indazoles as potent Rho kinase inhibitors and vasorelaxation agents, Yangyang Yao†,Renze Li†, Xiaoyu Liu, Feilong Yang, Ying Yang, Hongguang Yang, Xiaoyu Li, Xiang Shi, Tianyi Yuan, Lianhua Fang, Guanhua Du, Xiaozhen Jiao*, Ping Xie*. Molecules, 2017, 22, 1766-1781. (IF=3.098 )
11. Total Synthesis and Stereochemical Revision of Xiamenmycin A. Xiao-zhen Jiao, Yang-yang Yao, Bei-bei Yang, Xiao-yu Liu, Xiao-yu Li, Hong-guang Yang, Li Li, Jun Xu, Min-juan Xu,*Ping Xie,* Organic & Biomolecular Chemistry, 2016, 14,1805-1813. (IF=3.564 )
12. Concise and Efficient Synthesis of Eliglustat, Xiaoyu Liu, Xiaoyu Li, Hongguang Yang, Xiang Shi, Feilong Yang, Xiaozhen Jiao*, Ping Xie, Synthetic Communications, 2018, 48(5): 594-599. (IF=1.377)
13. Design, Synthesis of a Novel 4-O-methylsaucerneol Analogue LXY7824 as Potent HIF-1 Inhibitor and anti-Cancer Agent, Xiaoyu Liu, Xiaoyu Li, Feilong Yang, Yan Li, Xiaozhen Jiao*and Ping Xie Journal of Asian Natural Products Research, 2018, 20, 545–558. (IF=1.091)
14. Total Synthesis of Xiamenmycin C and All of Its Stereoisomers: Stereochemical Revision. Yang-yang Yao, Xiao-yu Liu, Xiao-yu Li, Hong-guang Yang, Li Li, Xiao-zhen Jiao*, Ping Xie *, Journal of Asian Natural Products Research, 2016, 18(10), 976-987. (IF=1.071 )

专著

专利

1. 咖啡酸苯乙酯类衍生物,其制法和其药物组合物与用途。谢平、李燕、焦晓臻、刘晓宇、唐梅、王勇、杜倩倩。ZL201910264532.9 授权日:2022-9-16,中国
2. 木脂素类天然产物4-O-甲基三白草醇的结构简化物,其制法和其药物组合物与用途。 李燕、谢平、刘晓宇、焦晓臻、杜倩倩、李晓宇、杨飞龙 ZL201711282043.3 授权日: 2022-3-15,中国
3. 3-(1H-吲唑)-四氢嘧啶-2-酮类化合物其制备方法及其用途,方莲花,焦晓臻,杜冠华,谢平,袁天翊,姚阳阳,陈俞材,张惠芳.申请号: ZL201610346543.8授权日:2021-7-6, 中国
4. 伊力格鲁司他的制备方法。谢平、刘晓宇、焦晓臻、李晓宇、杨红光、施翔、杨飞龙。ZL201810305457.1授权日:2021-1-12. 中国
5. 吲唑类化合物,其制备方法及其药物用途(中国)。方莲花、谢平、杜冠华、王丽萍、袁天翊、焦晓臻、王夙博、李人则、郭晶、宫丽丽 ZL201210172191.0授权日:2017-6-23. 中国
6. 三白脂素结构简化物其制法和其药物组合物与用途。谢平、陈晓光、 焦晓臻、刘晓宇、李燕、张翼、郎立伟、王丽萍、李人则. ZL201110141751.1授权日:2016-3-9. 中国
7. 2,3-二氢萘并[2,3-b]呋喃-4,9-二酮类化合物及其制备方法和用途。谢平、陈晓光、焦晓臻、施翔、刘晓宇、薛妮娜、季鸣、杜婷婷、王振伟。申请号:201910311646.4 申请日:2019.4.18,中国
8. 木脂素类衍生物及其制法和其药物组合物与用途。谢平、李燕、焦晓臻、刘晓宇、姜英俊、郑凯露、邓海东、王哲、王振伟、曹泱、吴媛媛 申请号:20210277262.2 申请日:2021.3.16,中国
9. Bysspectin A衍生物、其制备方法及其药物用途,焦晓臻,葛广波,吴媛媛,谢平,刘晓宇,宋云清,张雅,马波,李文萱,王苑,申请号:202210173634.1 申请日: 2022-2-24,中国
10. 一种咖啡酸类衍生物及其制法和药物组合物与用途,谢平,季鸣,焦晓臻,杜婷婷,刘晓宇,金晶,王哲,李文萱,申请号:202210701582.0 申请日:2022-6-21,中国
11. 2-苯基-4-酰基苯并呋喃类化合物、其制备及其用途,焦晓臻,葛广波,谢平,刘晓宇,李文萱,吴媛媛,张雅,胡丹阳,申请号:202211359718.0 申请日:2022-11-2,中国

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