2014年在北京协和医学院药物研究所获得博士学位，药物化学专业，导师雷平生研究员。一直从事非天然糖类化合物的合成及糖苷键的构建，对糖类化合物合成、结构解析有着丰富的经验。参与或主持了国家重大新药创制课题-抗G-耐药菌新药的发现与研发的子课题项目；创新药物发现与新技术专项-类具有高抗菌活性的酮内酯类抗生素的合成及生物活性研究；创新工程-复杂天然活性化合物的合成与新药先导物发现研究-任务2。

近五年一直从事非天然糖类化合物的合成及糖苷键的构建，意在发现高活性分子。具体研究方向为含糖苷键活性天然产物结构改造及构效关系研究；硫酸软骨素寡糖全合成、多糖半合成及成药性研究。共计发表sci论文十余篇，申请专利多项。

1. Synthesis and Antibacterial Activity of Novel 4′′-O-desosaminyl clarithromycin derivatives with 11, 12-arylalkyl side chains, Zhe-Hui Zhao, Di Zhu, Xiao-Xi Zhang, Zhi-Gang Luo, Ping-Sheng Lei*,JANPR, 2019, 7, 610-618.
2. Antibacterial activities of a series of novel 5-O-(4′, 6′-O-dimodified)-mycaminose 14-membered ketolides, Zhe-Hui Zhao, A-Peng Wang, Xiao-Xi Zhang, Shuang Yang, Zhi-Gang Luo, Ping-Sheng Lei*, JANPR, 2019, 5, 456–461.
3. An efficient and facile approach for construction of chondroitin sulfate E oligosaccharides precursors, Guangyan Zhang, Qi Liu, Shuang Yang, Zhehui Zhao*, Pingsheng Lei*, CCL, 30 (2019) 686–689.
4. Synthesis of novel 5-O-(6′-O-modified)-desosamine 14-membered ketolides, Zhehui Zhao, Apeng Wang, Xiaoxi Zhang, Shuang Yang, Zhigang Luo, Pingsheng Lei*, CCL, 30 (2019) 425–427.
5. The synthesis and biological evaluation of chondroitin sulfate E glycodendrimers, Shuang Yang, Haijing Zhang, Qifeng Liu, Shanshan Sun, Pingsheng Lei, Zhehui Zhao*, Lianqiu Wu& Yinghong Wang, Future Med. Chem. (2019) 11(12), 1403–1415.
6. Two novel N-glycoside 17, 18-unsaturated acid quinolin-3-ylmethyl ester josamycin derivatives, Zhehui Zhao, Longlong Jin, Apeng Wang, Shuang Yang, Pingsheng Lei, TL, 2018, 59, 1208-1211.
7. synthesis and antibacterial activity of novel ketolides with 11,12-quinoylalkyl side chains, Zhe-hui Zhao, Xiao-xi Zhang, long-long Jin, Shuang Yang, Ping-sheng Lei, BMCL, 2018, 14, 2358-2363.
8. An Approach to Synthesize Chondroitin Sulfate-E (CS–E) Oligosaccharides Precursors, Yang, Shuang; Liu, Qi; Zhang, Guangyan; Zhang, Xiaoxi; Zhao, Zhehui*; Lei, Pingsheng, JOC, 2018 83, 5897-5908.
9. Synthesis and antibacterial activities of some novel 17, 18-unsaturated carbonyl compounds derivated from josamycin, Zhehui Zhao†, Longlong Jin†, Yanpeng Xu, Chao Liu, Apeng Wang, Pingsheng Lei*, JANPR, 2017, 4, 358-387.
10. An investigation of construction of chondroitin sulfate E (CS-E) repeating unit, Shuang Yang, A-peng Wang, Guangyan Zhang, Xiangjie Di, Zhehui Zhao*, Pingsheng Lei, Tetrahedron,72(2016), 5659-5670.
11. Synthesis, conformational analysis and SAR research of OSW-1 Analogues, Chao Liu, A-peng Wang, Longlong Jin, Yanshen Guo, Yan Li, Zhehui Zhao*, Pingsheng Lei, Tetrahedron 72 (2016) 4091-4102.
12. An efficient method to synthesize novel 5-O-(6’-modified)-mycaminose 14-membered ketolide, A-Peng Wang, Chao Liu, Shuang Yang, Zhehui Zhao*, Pingsheng Lei*, Tetrahedron,72(2016), 285-297.

1， 含有喹啉取代基的红霉素A酮内酯类抗生素衍生物、其制备方法及应用，中国，靳龙龙，雷平生，赵哲辉，ZL201410520787.4，20190702。
2， 红霉素A酮内酯类抗生素衍生物、其制备方法及应用，中国，赵哲辉，靳龙龙，雷平生，ZL201610118615.3，20191213。
3， 硫酸软骨素多糖半合成制备方法和应用，中国，赵哲辉，雷平生，吴练秋，杨爽，王文杰，张海婧，李想，201910163208.8，20190305。
4， 硫酸软骨素多糖，其半合成制备方法和应用，PCT，赵哲辉，雷平生，吴练秋，杨爽，王文杰，张海婧，李想。
5， 7-硝基苯并-2-氧杂-1,3-二唑脱氧氨基葡萄糖、其制备方法及应用，中国，赵哲辉，申竹芳，环奕，雷平生，杨爽，刘帅男，李彩娜，201811501558.2，20181210.
6， 含有氨基喹啉环的高抗菌活性红霉素A酮内酯类抗生素衍生物、其制备方法及应用，中国，赵哲辉，雷平生，张晓曦，杨爽，201811216765.3，20181018.硫酸软骨素寡糖、其制备方法和应用，中国，赵哲辉，刘启，张广艳，杨爽，王瑛璞，雷平生，201810033328.1，20180115.